2007

World's First Sex-Selected Dogs In January 2007, the world's first sex-selected dogs were born, demonstrating XY® Sex Selection Technology works in the canine world.

2006

World's First Sex-Selected Kittens In October 2006, the world’s first sex-selected domestic cats were born with their sex predetermined. The litter, produced from embryos fertilized with sexed sperm, was born at Audubon Center for Research of Endangered Species in New Orleans.

2005

World's First Sex-Selected Dolphin In October 2005 the world’s first sex-selected marine mammal, an Atlantic bottlenose dolphin, is born at SeaWorld San Diego via XY® Inc. sex-selection technology.   XY Inc. Signs Commercial License with Boviteq In March 2005 XY Inc. and L’Alliance Boviteq announces the signing of a commercial license agreement to apply XY® sex-selection technology to the Canadian cattle industry.

Mexico's First Sex-Selected Calves In February 2005 XY-Mexico SA d’CV, a subsidiary of XY Inc., works with major Mexican dairymen to produce Mexico’s first sexed calves via XY® Inc. sex-selection technology.

2004

IND Lifetech and Evergen Report Birth of Sex-Selected Calves In November 2004 IND Lifetech and Evergen, which each hold pre-commercial licenses to produce cattle embryos for shipment to China, reports the birth of their first calves in China.

XY Inc. Signs Historic Agreement with Chinese Dairy Industry In August 2004, XY Inc. and DakoCytomation jointly sign an agreement worth more than $10 million to work with GoldCattle Bio. Inc. and China National Animal Breeding Stock Export/Import Corporation (CABS). The aim of the agreement is to improve the quantity and quality of the dairy herd in China, and in turn, to substantially increase milk production in that country. Inguran Begins Commercial Sales of Sexed-Semen Services In April 2004 Inguran, XY Inc.’s first commercial U.S. licensee, begins to offer complete sexed-semen services in conjunction with bulls custom collected at Genetic Resource International Inguran is located in Navasota, Texas. XY Inc. Signs Commercial Agreement with Trans Ova In March XY Inc. and Trans Ova Genetics, the global leader in embryo production and transfer, signs an agreement that allows Trans Ova, located in Sioux Center, Iowa, USA, to provide its customers with sexed cattle embryos.

Goyaike Begins Commercial Sales of Sexed Cattle Sperm In 2003, Goyaike S.A, a leading cattle-breeding company in Argentina, begins commercial sales of sorted cattle sperm in that country. Birth of XY-Mexico XY-Mexico launches in July 2003. Licensed to work with Mexican dairy and cattle farmers, XY-Mexico, CA d’CV, Torreon, Mexico, will soon begin its first commercial sales of sexed straws of bull sperm. USDA Supports Licensing Arrangements In October 2003, the USDA completes its due diligence on XY Inc., and the company meets all required standards. XY Inc. now receives active USDA support for its new licensing arrangements in the United States and other jurisdictions.

First Lady First Lady is born, the world’s first foal produced from Call Me Madam, the world’s first sex-selected filly in 1998, and Augustus Primus, the world’s first sex-selected colt in 1999. Researchers sorted the stallion sperm for only female-producing sperm. First lady was conceived using 17 million sperm – just 3 percent of the recognized “standard” dosage used with artificial insemination in horses.

Ballerina XY Inc. worked with Australian researchers to combine sex-sorted equine sperm with embryo transfer to successfully produce Ballerina, whose dam is a high-quality polo mare.

World’s First Sex-Selected Lambs XY Inc. and Sydney University announce the world’s first sex-selected lambs conceived using low doses of sperm that were sorted, then frozen, thawed and artificially inseminated into ewes.   Star Man Star Man is born, the world’s first foal produced using “fresh-shipped,” sorted, low-dose sperm via A.I.   Another World First with ICSI XY Inc.’s German collaborators produce piglets using sexed sperm and the new technique of intracytoplasmic sperm injection (ICSI) – another world first.

Breakthrough in Switzerland XY Inc. and Big X announce Switzerland’s first sexed dairy calves using artificial insemination   La Luna and Alexander the Great XY Inc. announces the births of La Luna and Alexander the Great, the world’s first filly and colt produced via artificial insemination and 5 million sexed sperm (just 1% of what is generally regarded as a minimal dose of 500 million sperm).   Nadine XY Inc. announces the birth of Nadine, the world’s first filly produced via artificial insemination and low-dose sexed, frozen, thawed sperm.

World’s First Sex-Selected Foals XY Inc. produces world’s first sex-selected foals using sexed semen and A.I.   World’s First Sex-Selected Calf XY Inc. produces world’s first sex-selected calf using frozen sexed semen and A.I.

1998

Call Me Madam XY Inc. produces Call Me Madam, the world’s first sex-selected foal.

XY Inc. Acquires Mastercalf of U.K. and achieves world control of the sexing technology of animals. XY Inc. also produces its first sex-selected calf by artificial insemination.

XY Inc. Formed A collaboration between the Colorado State University Research Foundation and Cytomation, the world’s leading flow-cytometer manufacturer, results in the establishment of XY Inc. in Fort Collins, Colorado, USA.

Separation of X- and Y-Bearing Sperm Further advances in flow cytometry and low-dose insemination permit Colorado State University researchers to produce the world’s first sex-selected calf by artificial insemination.

1992

First Sex-Selected Calf Mastercalf, Ltd., of Cambridge, U.K., produces world’s first sex-selected calf by in-vitro fertilization.

Late 1980s

Separation of X- and Y-Bearing Sperm Flow cytometer first used to separate semen into X- and Y-bearing sperm, but sperm not viable.

1970s

Flow Cytometer Equipment first developed to sort living cells at high speed.

1950s

Frozen Sperm Sperm that is deep-frozen then thawed is shown to produce healthy offspring. Today, 99% of all A.I.’s in the U.S. and U.K. dairy industries use frozen/thawed semen.

1910

Artificial Insemination Humans place bull semen into a cow’s reproductive tract. Today, more than 65% of U.S. dairy herds, 85% of U.K. dairy herds and 90% of Scandinavian dairy herds are bred by A.I.

1860

Mendel First scientific appreciation of how traits of offspring are directly passed down by both parents from generation to generation.

1780

Spallanzani First well-documented artificial insemination using dogs.

460-370 B.C.

Hippocrates First to record interest in controlling sex of offspring.

8,000-6,000 B.C.

Humans Begin Herding Animals Mesopotamia – sheep Egypt – cattle & goats China – ponies Mid-East – camels South America - llamas